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Lactams, Macrocyclic

LACTAMS forming compounds with a ring size of approximately 1-3 dozen atoms.

A group of LACTAMS with an aliphatic ansa chain which is linked to a BENZENE or NAPHTHALENE chromophore. Included are RIFAMYCINS, naphthomycins, geldanamycins, streptovaricins, and maytansinoids.


Lactams

Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.

Lactams

Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.

Benzene

Toxic, volatile, flammable liquid hydrocarbon biproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.



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