Jaundice, NeonatalA transient unconjugated hyperbilirubinemia that occurs between the second and fifth days of life because the hepatic enzyme GLUCURONOSYLTRANSFERASE required for BILIRUBIN detoxification is inadequate.
HyperbilirubinemiaPathologic process consisting of an abnormal increase in the amount of BILIRUBIN in the circulating blood, which may result in JAUNDICE.
LifeThe state that distinguishes organisms from inorganic matter, manifested by growth, metabolism, reproduction, and adaptation. It includes the course of existence, the sum of experiences, the mode of existing, or the fact of being. Over the centuries inquiries into the nature of life have crossed the boundaries from philosophy to biology, forensic medicine, anthropology, etc., in creative as well as scientific literature. (Random House Unabridged Dictionary, 2d ed; Dr. James H. Cassedy, NLM History of Medicine Division)
GlucuronosyltransferaseA family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.
BilirubinA bile pigment that is a degradation product of HEME.
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