Diabetes Mellitus, LipoatrophicA type of diabetes mellitus that is characterized by a paucity of adipose tissue (LIPODYSTROPHY) and severe INSULIN RESISTANCE. There are several forms involving any one of a number of genes encoding nuclear protein LAMIN TYPE A; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA; or other proteins.
An autosomal recessive form of diabetes, characterized by the generalized lipoatrophy.
An autosomal dominant form of diabetes characterized by the face-sparing partial lipoatrophy.
InsulinA protein hormone secreted by beta cells of the pancreas. Insulin plays a major role in the regulation of glucose metabolism, generally promoting the cellular utilization of glucose. It is also an important regulator of protein and lipid metabolism. Insulin is used as a drug to control insulin-dependent diabetes mellitus.
GenesSpecific sequences of nucleotides along a molecule of DNA (or, in the case of some viruses, RNA) which represent the functional units of HEREDITY. The majority of eukaryotic genes contain coding regions (CODONS) that are interrupted by non-coding regions (INTRONS) and are therefore labeled split genes.
|